Plainville Back Pain Related to Inflammation Reduced with Melatonin
Inflammation. Disc Degeneration. There is a relationship. Inflammation is the body’s response to harmful stimuli (injury, pathogens, metabolic stress – a disc herniation pushing on a nerve!) as it attempts to restore itself to normal before the harm was achieved. Layden Chiropractic is always amazed at how the body takes care of itself! Layden Chiropractic sees its Plainville chiropractic care as a partner of the body’s system in healing especially when spine pain is an issue. Chiropractic care uses many tools like spinal manipulation, exercise, and nutrition to help the body. Melatonin is one nutritional tool that is proving value in its ability to interrupt the inflammatory process related disc herniation that brings about pain relief: back, neck, spine-related.
DISC DEGENERATION AND INFLAMMATION AND 'AUTOPHAGY'
Inflammatory markers interleukin-1β (IL-1β), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) are related to intervertebral disc degeneration. (1) IL-1 β actually promotes itself, its own expression, by upregulating NLRP3 inflammasome activation. (2) The body controls itself down to the cellular level via autophagy, the natural process via which the body’s cells clean out damaged (ie, by inflammation) or unneeded parts. In a new study, melatonin increased autophagy and reduced the degradation of the disc’s extracellular matrix (technically indicated by a decline in marker LC3B, autophagasomes and autolysosomes and inhibition of the NF-kB signaling pathway). The end conclusion was that melatonin prevents intervertebral disc degeneration by stimulating autophagy. (3) Wow. Layden Chiropractic is encouraged by this research to see just how well melatonin can work for Plainville back pain related to disc degeneration.
MELATONIN AND ITS HEALING WAYS FOR THE DISC
Disc degeneration is a very common condition seen at Layden Chiropractic making positive news like this quite rousing. A recent study explained how melatonin could modify the extracellular matrix of the disc remodeling process started by IL-1 β. Additionally, melatonin reduced the inflammatory cell collection and decreased the release of associated inflammatory markers IL-1β, IL-6, and TNF-α. With this new finding that melatonin disrupted the IL-1B feedback loop, researchers postulated that melatonin may contribute to the restoration process of intervertebral discs after damage was already present. (1) Layden Chiropractic continues following the new research on the role inflammation performs in Plainville disc degeneration and melatonin’s role in reducing it.
INFLAMMATION AND MELATONIN
The significance of melatonin in helping to slow or stop painful conditions due to inflammation is increasing. The description of melatonin as a multitasking molecule affecting mood, immunity, and energy among other mechanisms is quite apropos. It is also anti-oxidant, anti-aging, and anti-inflammatory, specifically by hindering the activation of inflammasomes (4) Melatonin’s formal chemical name is as about as long as its list of tasks: N-acetyl-5-methoxytryptamine. The pineal gland secretes melatonin naturally. Melatonin influences the body’s aging, anti-inflammatory, anti-apoptosis (cell death), and autophagy (cell-cleanout) processes. (1) Melatonin’s specific influence on inflammation and disc degeneration is most attention-getting to Layden Chiropractic and our Plainville back pain patients.
CONTACT Layden Chiropractic
Listen to this PODCAST with Dr. Hrefna Sylvia based in Iceland where back pain isn’t much different from any other country on The Back Doctors Podcast with Dr. Michael Johnson as she illustrates how The Cox® Technic System of Spinal Pain Management manages disc degeneration for relief of chronic low back pain in her patient.
Schedule your Plainville chiropractic appointment with Layden Chiropractic now. We can talk about the role inflammation plays in your back pain experience and how melatonin may address the related disc degeneration.
