Inflammation. Disc Degeneration. There is a relationship.
Inflammation is the body’s response to harmful
stimuli (injury, pathogens, metabolic stress – a disc herniation compressing a nerve!) as it attempts to restore itself to normal
before the harm was achieved. Layden Chiropractic is never
shocked at how the body takes care of itself!
Layden Chiropractic sees its Plainville chiropractic care as a partner of
the body’s system in healing particularly
when spine pain is an issue. Chiropractic care utilizes
many tools like spinal manipulation, exercise, and nutrition to take care of
the body. Melatonin is one nutritional tool that is showing value
in its ability to interrupt the inflammatory process
related disc herniation that brings about pain relief: back, neck, spine-related.
DISC DEGENERATION AND INFLAMMATION AND 'AUTOPHAGY'
Inflammatory markers interleukin-1β (IL-1β), interleukin-6
(IL-6) and tumor necrosis factor-α (TNF-α) are linked to intervertebral disc degeneration. (1) IL-1 β in fact promotes
itself, its own expression, by upregulating NLRP3 inflammasome activation. (2)
The body controls itself down to the cellular level
via autophagy, the natural process via which the body’s
cells clear out damaged (ie, by inflammation) or unneeded parts. In
a new study, melatonin increased autophagy
and reduced the degradation of the disc’s
extracellular matrix (technically marked by a decline
in marker LC3B, autophagasomes and autolysosomes and inhibition of the NF-kB
signaling pathway). The end conclusion was that melatonin prevents
intervertebral disc degeneration by stimulating autophagy. (3)
Wow. Layden Chiropractic is encouraged by this research to see just
how well melatonin can perform for Plainville back pain linked
to disc degeneration.
MELATONIN AND ITS HEALING WAYS FOR THE DISC
Disc degeneration is such a common condition
seen at Layden Chiropractic making positive news like this quite rousing. A recent
study stated that melatonin could modify
the extracellular matrix of the disc remodeling process initiated
by IL-1 β. Further, melatonin reduced the
inflammatory cell collection and reduced the release of connected
inflammatory markers IL-1β, IL-6, and TNF-α. With this new finding
that melatonin disrupted the IL-1B feedback loop, researchers
proposed that melatonin may provide
the restoration process of intervertebral discs after damage was
already present. (1) Layden Chiropractic continues
following the new research regarding the role inflammation has
in Plainville disc degeneration and melatonin’s role in tackling
INFLAMMATION AND MELATONIN
The importance of melatonin in helping
to slow or stop painful conditions due to inflammation is growing.
The description of melatonin as a multitasking molecule affecting
mood, immunity, and energy among other things is quite apropos.
It is also anti-oxidant, anti-aging, and anti-inflammatory, specifically
by hindering the activation of inflammasomes (4) Melatonin’s
formal chemical name is as about as long as its list of tasks: N-acetyl-5-methoxytryptamine.
The pineal gland produces melatonin naturally. Melatonin influences
the body’s aging, anti-inflammatory, anti-apoptosis (cell death), and autophagy
(cell-cleanout) processes. (1) Melatonin’s specific effect on
inflammation and disc degeneration is most interesting
to Layden Chiropractic and our Plainville back pain patients.
CONTACT Layden Chiropractic
Listen to this PODCAST
with Dr. Hrefna Sylvia based in Iceland where back pain isn’t much different
from any other country on The Back Doctors Podcast with Dr.
Michael Johnson as she illustrates how The Cox® Technic
System of Spinal Pain Management manages disc
degeneration for relief of chronic low back pain in her patient.
Schedule your Plainville chiropractic appointment with
Layden Chiropractic today. We can talk about how inflammation affects your
back pain and how melatonin may address the related disc